I have a friend who has the Yamaha mixer with 3 power amps. Seeems to have enough power, but the effects are primitive.
I have found that the powered speakers (I still have those old out-dated EON 15's) sound great, but I'm not sure they really save that much setup time. Each has it's own power cord and balanced mic cable for input. With my old rack-mount system, I could leave everything connected. Just roll in the rack, plug in the keyboard, mic and speakers and play. Not much difference in setup time, really.
Of course to get the efficiency of the powered speakers, you would need to bi-amp, and this means extra stuff in the rack--crossovers and more cables. I'm half-way glad I don't have any money, so don't have to consider a change.