In theory, it's as simple as using one as LEFT and the other as RIGHT. In practice ... only a test will tell. I'm pretty sure it'll sound great. If I had both, I'd set the Nano facing ME and the Bose facing front. That way you get the cushy, sappy stereo chorusing, and the Bose fills the room more completely with no dead spots or sweet spots. That's an overkill situation, but makes sense in my twisted mind.