mmm..ok..lets try you to change the buffer, maybe will resolve some under wine but then we lose some latency..
Open your file manager and shown also the hidden files.
in your home you will find the .jackdrc
This is the setup jack configuration file when booting the OS.
double click and wil open with kwrite.
inside you will see:
/usr/bin/jackd -R -t10000 -dalsa -dhw:0 -r44100 -p128 -n2 -Xseq
the: -p128 = mean the buffer frames, you can edit ONLY the numbers like to: 32, 64, 128, 256, 512..and so on
try to set to 256, save the file and reboot
test if wine work better or then try to give more buffer, like on windows, normally they use 512 frames buffer.
If you will return back, just set at 128 and save.
Test and let me know
IF we find a good compromise, then I will update on the next OS too.