The reason, IMO, there is no quick start, for software arrangers, is because there are many possible hardware/software scenarios.
Your computer might have a Soundblaster or Audigy soundcard, in which case you could load soundfonts onto the card itself. If your soundcard can't load soundfonts, then you would need software to host the soundfonts.
If you use Hypersonic, then you don't need a host, but you would if you purchased a vst.
NI B4 could be used standalone or with a vst host. The list of possibilites are numerous.
Starkeeper