I think there is a huge difference, i usually use Sampled drums on anything, not just on PA.
I have like 10 drumkits from machines like ES, XS, FANTOM, BATTERY, G1000, G600,
KETRON SD, ALESYS SR-16 and few others sampled and i use them on hard or soft synths.
It really took a great deal of time and work but it was worth it, i produced them profesionally,
the ones with MultiLayers are reproduced the same way in MultiLayers and stuff.
I personally never liked Korg drums and i had to do something. M3 drums are useless.