Of course it's possible...the Doors did it...Jimmy Smith, Richard "Groove" Holmes and all those great old B3 players did it, and most importantly, almost everyone that does sequences does it. If you listen to any arranger, baselines were generally done playing left hand bass.

At first, when you play left hand bass live it's kind of like patting your head and rubbing your stomach at the same time, but you eventually get in synch.

Russ