This is also a good way to make a seamless transition in the middle of a song when changing keys.
At the end of the phrase where you want to transpose (say from F to F#), press Fill #2, immediately press transpose, and immediately press Fill #1. This will change key along with playing a little riff and the MSA rhythm and voicing will be unchanged. It usually sounds pretty good.
Of course you can press Fill #1, transpose,then Fill #2 and it will sound a little different