Could it be a voice that uses portamento and the effect is bleeding?  Sometimes fast passages on voices that use portamento can bleed into your run carrying over to adjacent notes thus resulting in a muffled sound.
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GEAR:  Yamaha MOXF-6, Casio MZX-500, Roland Juno-Di, M-Audio Venom, Roland RS-70, Yamaha PSR S700, M-Audio Axiom Pro-61 (Midi Controller).  SOFTWARE:  Mixcraft-7, PowerTracks Pro Audio 2013, Beat Thang Virtual, Dimension Le.