I almost never change the preset voices. I like two above mine and one below. Sometimes I drop the one below another octave for a 50's sound, but that's mostly it.
I use a TON of harmony, and I don't overuse it a bit. My sound is based on a 4 freshman type ensemble, and I would be so lonely without it. Since I got the Voice prysm, I am spoiled but I remember a feature on the Digitech that allowed for those smooth slides into and off of a note. The key to a harmonozer is balance. There is only ONE correct level. Too much sounds fake, too little sounds whimpy . Find the sweet spot, and stick with it.
I really have no need for lots of presets, because I trigger the notes from the right hand. That way the chords are always fresh and interresting with lots of passing tones and such. If the arranger section drives the harmonizer, the chord structure suffers a little. Unless you have a monster left hand. I don't. I play simple chords with the left, if any. Mostly - it's left hand bass and right hand chords for my arrangenments.
Find "your" sound for the voice and just turn it on and off. I wouldn't worry about too much "hands on" time with a harmonizer. The chords it reads should provide all the variety it needs.
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