Hi John

With difficulty

Seriously I spent most of my life playing rhythm guitar or bass and singing harmony. I'll have to practice my "chord melody" playing or rely on fills and hope my singing is good enough to carry me through.

The latency seems very good so there isn't a noticeable delay when playing single strings. The SD40 only recognises chords with three notes so it's possible if you are a decent guitarist to play lead using three string chords and single strings

Regards, Col