I have used Two and also just One Bose Compact speakers on gigs since the Compacts first came out. The very best scenario is to place the speaker about 2 or 3 feet behind you or just to the side and behind you. When using just one make sure you run two cables from both the R/LR outputs into the Bose using a combining plug available at Radio Shack.
Often I am forced to place the speaker right next to the keyboard and that works ok too when necessary. I have run my mic into the keyboard and have also run it right into the Bose itself. I don't sing so either way works for me. I have never uses a mixer into the Bose - do all the EQ on the keyboards(Tyros 4 and Ketron SD7).
One word of caution - the Bose Compact can product a lot of Bass - especially if you must place it close to a wall when playing. Be prepared to EQ that out on the fly if necessary.
Every place I have played I have gotten rave comments about how great the sound is. The Bose is a great system and i'm sure you will like it a lot.
Deane