I am not sure what kind of sound separation there may be in the back of a hall far from the speakers, but to me there is a difference in sound quality ... going back to my kn6000 I could hear the difference when using 2 speakers vs 1 ... on those occasions when I use 1 speaker I always use a Y connector so that I am at least sending both left and right signals into the one speaker ... there may not be any sound separation, but at least both right and left sounds are heard ...

And I have never seen a DJ use only one BOSE ... just sayin' ...