I am not that familiar with Karma, but the one area that I find to be non-intuitive in most of these loop and arp players (MoXS, FantomG, M3/50 etc.) is the matter of triggering arps.
So far, from what I have found out (correct me if I'm wrong), there is NOTHING similar to how arrangers fills work. That is, although arranger fills are one or two (or more) bars long, you can trigger them at any point in a bar, and they will commence playing immediately, but here's the most important thing...
they commence from the correct point in the bar that they are triggered on.
So far, all I can find are arps that either start on the 'one', at the end of the bar no matter WHEN in the bar you trigger them, or ones that commence immediately (or on the NEXT beat), but they STILL start on the 'one'...
So... you ask fro a fill on the 'three' and you have a choice between waiting until the one (by which time, it is too late), or getting the fill immediately, but it now is out of sync (the 'one' is now a beat or two too early) and so are your subsequent bars.
Neither of these options are, IMO, musical. Fine, if you like, for music that basically doesn't HAVE fills, or fine for DJ's that can afford to think a bar or two ahead (because they are playing very little themselves), but for pretty much anything OTHER than straight ahead DJ type music (including much modern music - alternative rock, emo, basically anything played by HUMANS

), pretty much useless.
Until this is fixed, I'm afraid that Karma (if so hobbled) and other loop tools just don't cut it. They stifle spontaneity and creativity in all but DJ style music. If you have any dialog with the designers of these types of instruments, the arranger system of fills needs to be added to current triggering options before many of us (including those that DO a bit of loop music) can really use them for day to day operation.
It honestly seems that so little needs to be added before we can all adopt them without the paradigm shift in the way we play them needing to be changed (for the worse!)...