Yes, at least for a singer, the tendency is to play the head, or verse and chorus BEFORE you start soloing, so the chord sequencer has time to pick up the changes before you need it to start playing.

Instrumentals, you usually go with a piano verse or head first. In Pianostyle Mode, this helps get inversions and slash chords into the CS. Or a simple, 'just the facts, ma'am' melody sound. Then, once you have gone through the head the first time, now you have the sky as the limit the second time.

I honestly roll my eyes when I hear from people that say they tried the CS, but didn't use it much What's not to like? If you have a decent solo technique, it's about the ONLY way to use it...