Don's right - it's not a question of transposition, but rather finger-position! Some things are almost impossible in some keys .... like certail blues licks that involve sliding up to a note (like a grace note) Try the same riff in "E" and "F" it becomes entirely different.
The transpose button becomes a digital capo - a most needed, highly professional tool to aid the performance of difficult, or otherwise impossible passages.
Sure, it can be mis-used, or overused, but the fact that it exists, is a good thing.
(learn to play in lots of keys anyway - it's good exercise for the hands, and makes the music sound fresher when chords are voiced differently.
Like all things ....... "Moderation is best"