The Mackie 350's are amazing speakers in a small scenario for easy listening 50-100 pp... you would need a small sub to get some more bottom end for dance music........

The 450's can be very very proficient and my choice for most medium size gigs 100-250 pp excellent clean power & ample bass....
& if you add a Mackie Sub to them
WATCH OUT!!!! I love em they wont let you down!
www.mackie.com