I've had the Roland BA330, the Nano 300 and a Roland Cube Street.  None of them could compete with the Bose Compact.  My only other go to is an EV ZXL12p 2-way powered speaker which is a completely different animal.  The S1 Pro is very attractive and might make a nice addition to my little setup, but at $599 I'm going to pass.  No doubt it's a great unit; I just don't need it.
IMO, Roland's biggest downfall is its speakers.  I haven't played one Roland amp that sounded good with keyboards except the JC 120. Give me an EV or a Bose and I' happy.  BTW, my next purchase will most likely be a Fender Deluxe Reverb, mostly for nostalgia.  Know of one collecting dust?