If you’re using 2000, XP or Vista you can use the Recovery console to gain access to the file before Windows starts, and then just delete the file.
If its not already been loaded, then it can be accessed using the OS disks; proceed as if you are installing or re-installing Windows but choose the R (Recovery) mode to access the console, and then use command mode. (If your not sure what commands to use just type help (If you are used to DOS you will have little problem adapting to the NTFS version)
Hope this helps

Bill