Lastly, lead guitar sounds...

For me, the only place to start is the SN Jazz Guitar patch. This is a brilliant piece of programming that helps keep single lines clean but still allows chords. Feed it into the full MFX Amp Sim (not at my keyboard right now, so can't tell you it's proper name) but it's the one with all the different models... Twin Reverbs, Soldano's, Marshall's etc.).

From here on out it's just mess around with the different models until you find what you're looking for. I'd recommend not having the volume on the Part too high. The input feels a lot more alive not overloading the input. But there's a ton of variety in there. Try to find an overdrive setting that doesn't muddy up chords TOO much but gives nice sustain on the held notes and just grunges up the chords about right.

Now, effects... Rock guitars are nothing without echo! But you just used up your one MFX! What to do? Here's where it gets good. Leave your reverb send alone (you'll need that for other Parts) but change your Send Effect #2 from chorus to Delay. But... DON'T SEND TO REVERB AND DELAY FROM THE MIXER. There are sends from WITHIN the amp sim MFX. The sends from the mixer are pre-MFX. The sends from the MFX are post-effect. You want to echo up the distorted sound!

One last caveat... input AND output level of the and sim can change the sound, so if you get a great sound but it's too loud, dial back the 'mic level' parameter in the sim. Plus, it does change the sound a hair, but you can put MFX output on one of the Control sliders, so you can shade its volume a hair in realtime.

Just remember, mixer volume or expression pedal changes the PRE-MFX send, so riding it with your feet will definitely change the amount of distortion. So the only place to make a simple post-MFX volume change is the slider.

Now, back to the echo... For styles and SMF's that have a defined tempo, set your delay repeats to the needed division for the tune... 1/8, 1/4Triplet etc. For an audio file, you either need to set up the correct tempo (using a style) BEFORE you load up the audio file, or tap the tempo as the track plays every time. This is cool because you can change the echo timebase during a song, or 'push or pull' the repeats slightly to get a pushy or laid back echo effect. Plus great for playing with bands to set echo timing to match a live drummer....

This ought to get you going!