Hi Bernie,
I think the main thing will be in deciding how you want to set up and use your registrations and playlists.

You don’t want to start doing it one way, and then decide halfway thru the alternative might have been the better option.

My method I believe may be similar to John’s . One song, 1 bank of registrations. That way the registrations can be fine tuned or changed along the way, without impacting on other songs.

May or may not be the best option for performance purposes, but for me it’s working out well.