A very interesting topic and one which will go on and on, I'm sure.
I have great respect for anyone who sequences their music, not to mention admiration for their patience. In fact I respect anyone who produces music by whatever means. I've backed singers who sing in the key of Z - but at least they have a go. Firstly if it gives you pleasure producing music by that method all well and good. Secondly if the 'listener' enjoys the music for what it is, not how it was produced so much the better. Even Mike Oldfield played some tracks of his famous 'Tubular Bells' at half speed!!! and that's a CD I've nearly worn out.
Having said all that, I'm a 'warts and all' live player and have never used a sequenced song at any of my gigs.
John