I've been using two Compacts since they came out. Nobody has ever said, "man you are missing some mids". And I can clearly hear every frequency range. Nothing is missing. \
Instead, a countless number of people, including musicians and/or singers, about how great it sounds.
Can't recommend them highly enough!
I run everything flat, as far as e.q. I may adjust slightly if the venue calls for it. Many people still use the old "V" pattern on their e.q. system, cutting mids and/or boosting highs and lows. This is not necessary on the Bose systems.
However, use whatever sounds good to you, and that you want to lug around! Until I hear something that beats the combination of sound and functionality that I have now, I'm set for life! Hope that is quite a while longer, btw.
:}