Donny, I've played my keytar with real guitarists forever. Never had one say a bad word. Admittedly, I rarely spend all my time playing guitar patches when I have a good guitarist right there, but I still like to freak 'em out a bit!
I did one gig where I sat in for a band member who couldn't make it who played guitar and fiddle, so just for fun, I stuck to just guitar and fiddle patches... That seriously weirded them out, seeing it all come from a keytar!
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An arranger is just a tool. What matters is what you build with it..!