That's a good question. I never know when to use ASIO, and how to configure it. Also, ASIO is audio, right ?. Does that pertain to midi drivers in any way ? Are samples, like in soundfonts, controlledby my midi or ASIO ?

Obviously, midi out from a sequencer carries instructions to a soundcard or sampleset. It then is processed into audio and to the speakers.

Am I missing something ?
pa4X 76 ,SX900, Audya 76,Yamaha S970 , vArranger, Hammond SK1, Ketron SD40, Centerpoint Space Station, Bose compact