You may want to try a system reset, which may help. This is down by holding down the Manual and Voice2 buttons while powering up. Hold them down for at least three seconds, after which the Harmony M should boot normally.

Gary
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PSR-S950, TC Helicon Harmony-M, Digitech VR, Samson Q7, Sennheiser E855, Custom Console, and lots of other silly stuff!

K+E=W (Knowledge Plus Experience = Wisdom.)