Jan Hammer did it with keyboards that were FAR less accurate than today's, but then again, he actually ran them through a tube amp cranked to 11 (OK, maybe 9!) to get the sound. Plus he looked at Jeff Beck, Al Dimeola and John Mclaughlin's guitar playing every night and copied what he could!

The thing is, it's easy to get ONE NOTE accurate for just about any sound, including distorted guitar. But a whole line, a whole piece, that's a fish of a different smell...
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An arranger is just a tool. What matters is what you build with it..!