Here are my settings:

1. left footswitch Fill to self
2. right footswitch glide

the glide function is really cool, it helps playing some of the instruments in a more real way, like Guitars, Sax, or Trumpet, by gliding into the note, like a real Sax or Guitar player would do.
When I'm improvising a solo, I'm often to busy with my left hand playing cords, so I can't use the modulation wheel. The glide function is a good compromise when used well.

I turn the VH on and off by hand.

Eric