comparing Motif ES with 2100 is easy. The quality of sounds in Motif ES are superior because the Motif contains huge memory that is supposedly utilized to hold better sampled sounds. That what I was told. In other words, if you want higher quality sounds, motif es, supposedly, will beat 2100 big time. That is not to say that 2100 is bad or that it is different. They are close enough for live performance but distant enough for professional recording.
Other than that, I would say that Motif es has no styles nor speakers.
The real comparison is between Tyros and Motif es. What is the difference? Are the sounds identical on both? We know that Motif es has the Mega voices. But we also know that it has tons of memory.