softlysoftly, I am not certain I understand what you mean by multi sample. If you mean that each note is sampled and each velocity level is sampled, e.g., one piano note can have 16 samples then yes kontakt will load such instruments. This assumes that your sampled instrument is in the native kontakt format or in a format which can be converted by kontakt. If you need to convert from another format say soundfont to kontakt then this can be a hit or miss business.

In addition, some of the high level instruments include key switching to allow for such things as guitar noises, sax growls and so on. These too would be additional samples for a given instrument. Some of the piano instruments have over 2 GBs of samples.

So if some of your instrumets work then that indicates to me you have everything installed properly. The problem may well be that the multi sample instrument you are trying to load is flawed or not converted by kontakt.