I have the VoicePrism, but have decided so far not to add the plug-in board. The basic VoicePrism comes with what I was looking for--Mic Input with Phantom power, Compression, EQ, harmony, and effects--mainly reverb for me. I think the VoicePrism interface is far superior to the Digitect interfaces, but that depends on what you are used to. I personally enjoy the voice "icons", but others may think they are too cute. I have not checked on how well one can switch between presets in a live situation.
I might get the physical modeling card simply because I have the slot, but I am not very excited about it. What it does is interesting, it converts one vocal inflection style to another--allowing you to add breathiness, graspiness, growling, etc. to an otherwise vanilla vocal. A recent report in one of the trade magazines indicated that one producer found this feature a life saver--applied to someone else's vocal track.
Unfortunately, from my perspective, the "effect" can only be applied to the lead vocal, not to the harmonies. In my case, the lead vocal is "me" and that's the one thing I want to preserve. What I would like is the ability to apply the physical modeling to selected harmony voices so it sounds like I am accompanied by someone other than myself. As far as the lead vocal, I just as soon do my own growling.