Han,
The only way you can blow out a speaker is to turn the volume up too loud. The signal coming out of the mixer is usually not sufficient to do this unless it's a powered mixer and you're using the speaker out instead of the line out. The line out is a constant level, therefore the signal going into the amplifier remains constant and the amplifier's volume control then controls how much signal is sent to the speakers--not the mixer. Give it a try, start out at low levels and if the volume level is insufficient for the crowd, take the Z-2200 back for a refund and go for something larger.
BTW: I had a country band over a few nights ago, we hooked up the Z-2200 to my Peavey mixer, and into the Peavey were two guitars, three mics and my PSR-2000. The room measures 36 X 28 feet, which is just over 1000 square feet. The gain on the Z-2200 was up half way and it was more than enough. Keep in mind, however, that there were only 8 people in the room, and most of us were playing and singing, therefore, we didn't have to contend with crowd noise. I don't know how much more volume I would have needed to deal with 60 or more folks if they were talking at higher than normal levels, which tends to be the case at some venues.
Gary
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PSR-S950, TC Helicon Harmony-M, Digitech VR, Samson Q7, Sennheiser E855, Custom Console, and lots of other silly stuff!
K+E=W (Knowledge Plus Experience = Wisdom.)