I definitely notice a difference. I'm guessing that this has to do more with the DSP effect settings than anything else.

You can make custom effect settings that mimic the panel ( voice mode ) voice and store in the sequencer, but this is where I always felt the Motif seqeucner was weakest, because the dsp settings don't seem to completely translate from voice mode to song mode.

I have to do this some of this mainly from memory and then trial and error, ( lol )because I rarely use the song sequencer, although I do use the pattern sequencer a bit.

AJ