I am with those who are advocating the latest software based systems including large sample libraries and virtual instruments, etc. (VSL, EWQLO, Scarbee, GPO, Bardstown, Hunter's Strings, VRSound, B4, RealGuitar, etc.). I have been using these or similar virtual instruments for years. All I can say is the proof is in the pudding. The big guys (move/screen writers, composers) use them all the time. I know I will not go back to hardware based solutions given the difference in overall quality even with some of the control surface sacrifices.

I have no trouble using my software based system for live performances (search flr2003 & flr2004). It all sounds so good!!! We live in interesting times.