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Are you using an external harddisk as well? Apparantly, using a firewire interface together with a firewire HD (on the same bus), can have disasterous effects! Please let me know, as I have been considering going this way.

What made you choose the RME 800? How many imputs does it have, and does it support digital audio?

The next thing on my shopping list (after I finish my current purchase of Kontakt 2) will deffinitely have to be an upgrade on my current USB audio interface.

Good luck with your setup!