I can't give you any feedback on the 2200s, but I do use the 5300s and they are great. I do not play large venues, most of my gigs are under 100 people. I find them easy enough to transport and they have the power I need. For the extra $30, IMHO I'd get the 5300s. Check this link out Gary has come up with a great way to easily transport the Logitechs. http://www.psrtutorial.com/Resources/musictips.html