And of course to return the the original topic, having met so many "nearly" keyboard players who couldn't cope with different keys and thus gave up; I dont see why you shouldn't use transpose to get you up and running.

Once you are confident in the "simpler" keys (I never thought about it before but Scottyee's right about C# being a nice shape for the hands) then you may get brave and try more complex stuff. Let us not forget that if you are playing a tune such as (say) "I Cant Smile Without You" then the key changes within the song are going to carry you away from C no matter what you do with the transpose settings to start off with!