SRM450's are brilliant. I've used these active speakers for over a year now for some smaller venues that I play at. It's great not having to carry 2 amps around! However, I use a larger system for bigger clubs (2 EV SX500 tops and 2 Martin Audio bass bins).
You can't go wrong with Mackie, EV or Martin stuff. On the mixer side of things, Yamaha do some good priced automated ones Promix 01 (great prices maybe second hand now) and 01V I think it is.