Hi Russ, the Firewire 410 is certainly a nice choice and well priced at $299, but after A/B ing it side by side with the 'Presonus Firebox':
http://www.presonus.com/firebox.html I opted for the slightly more expensive Presonus Firebox ($325) because it appears to me to be a lot more solidly built and with specific feature advantages.
I appreciate the Firebox for its solid build, impressive clean sound, quiet performance, & small & compact footprint. I especially appreciate that its knobs & panpots include infinite click points making it easy to customize & memorize the settings. To top this off, Presonus (a much smaller company) provides the BEST free online (800 number) technical support I've ever experienced. The Presonus tech support specialist took lots of time walking me thru the complete setup of not only the Presonus Firebox, but Cakewalk Sonar 4, and all my other music software as well, in getting them to work optimally together. How many other company's tech support specialists would offer to do this? Interestingly enough, I own an M-Audio Delta-66 soundcard, and can't remember M-Audio offering me that kind of service.
Scott