There is a new Cubase SX coming around that can be considered the best AUDIO/MIDI application ever. It is coming END of second quarter this year. It requires a good computer with XP OS (2K will do). In the mean time, do your research very carefully because I believe if buy Cubase 5.1 VST/32 AFTER certain date, you will be allowed to upgrade to CUBASE SX for free... if my memory serves me. If you are asking for now, I am a cubase user and I will recommend Cubase.