The Prodikeys is one of my favorite and most useful "toys" - and yes, it works just fine with any MIDI program or sequencer. I've had mine for over a year. After installing the software, all of your MIDI programs will see the Prodikeys as another MIDI input device. You must have a PS2 keyboard port (it's not USB unfortunately) so it may not work with your laptop. It also helps if you have a low-latency soundcard (it comes with Soundblaster Live! which doesn't do too badly). It also comes with some very cheesy child-oriented arranger software and it features 37 mini-keys - but those are the only negatives. I like to use it for creating rough drafts of songs. It's one of the handiest computer accessories I've ever owned - two thumbs up.

The newer "DM' model features octave shift buttons and sustain buttons that my original model does not have so I may have to upgrade at some point. Here's the website:
http://www.prodikeys.com/